Prelude Therapeutics Incorporated (NASDAQ: PRLD) Stock Information | RedChip
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Prelude Therapeutics Incorporated (NASDAQ: PRLD)
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$3.98
+0.3200 ( +8.74% ) 246.5K

Prelude Therapeutics Incorp is a clinical-stage precision oncology company focused on discovering and developing small molecule therapies optimized to target the key driver mechanisms in cancers with high unmet needs. The company's pipeline includes four candidates currently in clinical development: PRT1419, a potent, selective inhibitor of MCL1; PRT2527, a potent and selective CDK9 inhibitor, PRT3645, a next-generation CDK4/6 inhibitor, and PRT3789 a first-in-class SMARCA2/BRM protein degrader.

Clinical Trial Pipeline Stages


Drug Name Stage
PRT3645 (CDK4/6 inhibitor) + KEYTRUDA®DetailsCancer Phase 2
PRT543 (PRMT5 inhibitor)DetailsMyelofibrosis, Solid tumor/s, Myelodysplastic syndrome, Cancer Phase 1
PRT3645 (CDK4/6 inhibitor)DetailsHead and neck cancer, Glioblastoma, Non-small cell lung carcinoma, Breast cancer Phase 1
PRT2527 (CDK9 inhibitor)DetailsAcute myeloid leukemia, Hematologic malignancies, Solid tumor/s Phase 1
PRT3789 [SMARCA2 degrader]DetailsNon-small cell lung carcinoma, Cancer Phase 1
PRT7732 [SMARCA2 degrader]DetailsCancer, Non-small cell lung carcinoma Phase 1
PRT1419 (MCL1 inhibitor)DetailsHematologic malignancies, B-cell malignancies, Relapsed/refractory acute myeloid leukemia, Solid tumor/s Failed
PRT811 (PRMT5 inhibitor)Detailsprimary central nervous system lymphomas, Cancer, Glioblastoma Failed

Market Data


Open $3.98
Previous Close $3.66
Volume 246.5K
Market Cap $291.50M
Day Range $3.62 - $4.33
52 Week Range $0.75 - $5.54
Shares Outstanding 79.65M
Change % +8.74%
Net Change ▲ 0.3200
Insider Ownership 0.01%
Exchange NASDAQ
SectorHealthcare
IndustryMedicinal Chemicals and Botanical Products
IPO Year2020
CountryUnited States
UnderwriterIPO Intelligence Only

Insider Ownership Transactions

Total Amount Purchased: -1,863,877.00

Date Type Amount Purchased Purchaser
2024-06-18 Sale -23500.00 BAKER BROS. ADVISORS LP
2024-05-16 Sale -25000.00 Lim Bryant David
2024-04-08 Sale -9375.00 Huang Jane
2024-03-04 Sale -150000.00 Scherle Peggy
2024-03-04 Sale -150000.00 Combs Andrew
2024-03-04 Sale -150000.00 Chardonnet Laurent
2024-03-04 Sale -150000.00 Lim Bryant David
2024-03-04 Sale -425000.00 Vaddi Krishna
2024-03-04 Sale -175000.00 Huang Jane
2024-01-08 Sale -9375.00 Huang Jane

SEC Filings


Form Type Description Pages Date
10-q Quarterly Reports 67 Nov 12, 2025
8-k 8K-related 38 Nov 12, 2025
4 Insider transactions 1 Nov 07, 2025
8-k 8K-related 40 Nov 04, 2025
3 Insider transactions 2 Oct 20, 2025
4 Insider transactions 2 Oct 20, 2025
8-k 8K-related 12 Oct 17, 2025
4 Insider transactions 1 Oct 07, 2025
8-k 8K-related 10 Sep 19, 2025
10-q Quarterly Reports 66 Aug 14, 2025

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