| Annovis Bio (NYSE American: ANVS) Announces Positive Results from NIH Funded Chronic Toxicology Study |
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Annovis Bio (NYSE American: ANVS), a clinical-stage drug platform company addressing Alzheimer’s disease (AD), Parkinson’s disease (PD) and other neurodegenerative diseases, today announced it successfully completed the rat cohort of a chronic toxicology study of its lead therapeutic compound ANVS401, reporting no negative side effects.
Why It Matters: The six-month rat study was part of a series of animal toxicology studies, funded by a $1.7 million grant from the National Institutes of Health, that began in the fourth quarter of 2019. The safety seen in the rats corroborates the positive results from the Company’s prior one-month safety studies in mice, rats, dogs, and humans. A nine-month dog safety study remains ongoing under the NIH funded program, with results expected in the third quarter of 2020.
Key Quote: “The successful termination of our chronic rat tox study is another important milestone for Annovis. Our chronic toxicology studies, which enable us to conduct long-term human studies, provide a solid foundation for ANVS401 as we continue to focus on our current ongoing Phase 2a study in AD and planned two-armed Phase 2a study in PD and AD, ultimately positioning us to move into pivotal Phase 2/3 studies.” – Dr. Maria Maccecchini, CEO
The Backstory: Headquartered in Berwyn, Pennsylvania, Annovis is a clinical-stage, drug platform company addressing neurodegeneration, such as Alzheimer’s disease (AD), Parkinson’s disease (PD) and Alzheimer’s in Down Syndrome (AD-DS). Annovis is believed to be the only company developing a drug for AD, PD and AD-DS that inhibits more than one neurotoxic protein and, thereby, improving the information highway of the nerve cell, known as axonal transport. When this information flow is impaired, the nerve cell gets sick and dies. We expect our treatment to improve memory loss and dementia associated with AD and AD-DS, as well as body and brain function in PD. We have an ongoing Phase 2a study in AD patients and plan to commence a second Phase 2a study in PD and AD patients.
Disclosure
Annovis (ANVS) is a client of RedChip Companies, Inc. ANVS agreed to pay RedChip Companies, Inc. a $8,500 monthly cash fee, beginning in February 2020, for RedChip investor awareness services and consulting services.
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| CytoDyn (OTCQB: CYDY) Initiates Phase 2 Clinical Trial with Leronlimab for Treatment of NASH |
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CytoDyn (OTCQB: CYDY), a late-stage biotechnology company developing leronlimab (PRO 140), a CCR5 antagonist with the potential for multiple therapeutic indications, announced initiation of the Company’s Phase 2 clinical trial for the treatment of non-alcoholic steatohepatitis (NASH). The Phase 2 trial is designed to test whether leronlimab may control the devastating liver fibrosis associated with NASH.
Why it Matters: The Company’s preclinical study demonstrated strong positive data highlighting the potential of leronlimab in treating nonalcoholic fatty liver disease (NAFLD), a common precursor to nonalcoholic steatohepatitis (NASH). These data, along with previous findings showing that leronlimab inhibits liver fibrosis, suggests the potential of leronlimab to control both the early and late stages of NASH. There are currently no U.S. Food and Drug Administration (FDA) approved treatments for NASH and it is expected to be the number one cause of liver transplant by 20201. About 30 to 40 percent of adults in the U.S. are living with NAFLD, and 3 to 12 percent of adults in the U.S. are living with NASH.
Key Quote: “We are excited to continue to advance the evaluation of leronlimab for a potential therapeutic benefit for NASH, a disease with an increasing prevalence in the U.S. Our strategic plan to execute a multi-pathway approach to exploring all potential benefits of leronlimab has led to cancer, COVID-19 and now potentially NASH, along with other immunologic indications.” – Nader Pourhassan, Ph.D., President and CEO
The Backstory: CytoDyn is a late-stage biotechnology company developing innovative treatments for multiple therapeutic indications based on leronlimab, a novel humanized monoclonal antibody targeting the CCR5 receptor. CCR5 appears to play a critical role in the ability of HIV to enter and infect healthy T-cells. CytoDyn has successfully completed a Phase 3 pivotal trial with leronlimab in combination with standard antiretroviral therapies in HIV-infected treatment-experienced patients. CytoDyn filed its BLA in April 2020 to seek FDA approval for leronlimab as a combination therapy for highly treatment experienced HIV patients, and submitted additional FDA requested clinical datasets on May 11, 2020.
Disclosure
CytoDyn (CYDY) is a client of RedChip Companies, Inc. CYDY agreed to pay RedChip Companies, Inc., a $7,500 quarterly cash fee, beginning in May 2020, for RedChip investor awareness services. The CEO of RedChip Companies owns 3400 shares of CYDY.
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| Better Choice (OTCQB: BTTR) Partners with iHeartMedia to Support Animal Shelters Impacted by COVID-19 |
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Better Choice Company (OTCQB: BTTR) announced a partnership with iHeartMedia to provide support to animal shelters impacted by the ongoing COVID-19 pandemic.
Why It Matters: As part of the Better Choice Company COVID-19 Relief Initiative, sister brands Halo and TruDog have partnered together with iHeartMedia to donate $100,000 in monetary funds and $100,000 worth of product to shelters nationwide. The Company’s COVID-19 Relief Initiative included shelters in Atlanta, Phoenix, Indianapolis, Los Angeles, Long Island, and San Francisco.
Key Quote: “Donations play a large role for many animal shelters across the US. Through our partnership with iHeartMedia we hope to fill some of the void left by decreased donations during the COVID-19 pandemic.” – Werner von Pein, CEO
The Backstory: Better Choice is a rapidly growing animal health and wellness company committed to leading the industry shift toward pet products and services that help dogs and cats live healthier, happier, and longer lives. We take an alternative, nutrition-based approach to animal health relative to conventional dog and cat food offerings and position our portfolio of brands to benefit from the mainstream trends of growing pet humanization and consumer focus on health and wellness. We have a demonstrated, multi-decade track record of success selling trusted animal health and wellness products and leverage our established digital footprint to provide pet parents with the knowledge to make informed decisions about their pet’s health. We sell the majority of our dog food, cat food and treats under the Halo and TruDog brands, which are focused, respectively, on providing sustainably sourced kibble and canned food derived from real whole meat, and minimally processed raw-diet dog food and treats.
Disclosure
Better Choice (BTTR) is a client of RedChip Companies, Inc. BTTR agreed to pay RedChip Companies, Inc. a $10,000 monthly cash fee, beginning in June 2020, increasing to $15,000 monthly in August 2020, and $20,000 monthly in October 2020, for RedChip investor awareness services.
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| BioVie (OTCQB: BIVI) Announces Adds Highly Accomplished Executives to its Board |
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BioVie (OTCQB: BIVI), a clinical-stage company developing innovative drug therapies for liver disease, announced the appointments of Dr. Robert Hariri, Mr. Steve Gorlin, and Mr. Sig Rogich to its Board of Directors.
Key Quote: “We are humbled to have these industry titans join our company. Robert has leveraged his deep expertise in biology to pioneer and found leading-edge life science companies. Steve has been founder and initial investor in many successful biopharma companies. Sig has served multiple US presidents over the years and has been dedicated to improving Alzheimer’s disease patient care. The new directors join current member and industry leader Cuong Do, who was formerly Chief Strategy Officer at Merck & Co. and currently President of Samsung Global Strategy Group. The combination of unique talents and capabilities of these distinguished gentlemen will greatly benefit BioVie as we advance the Company.” – Terren Peizer, Chairman & CEO
The Backstory: BioVie is developing BIV201 (continuous infusion terlipressin) an Orphan Drug candidate for the treatment of ascites due to advanced liver cirrhosis. First-to-market Orphan therapies typically receive 7 years of market exclusivity in the US for the designated use(s). It is being investigated as a potential new therapy for patients suffering from ascites, and future development opportunities include hepatorenal syndrome (HRS) and other life-threatening complications of advanced liver cirrhosis. The initial disease target for BIV201 therapy is ascites, which is a serious complication of advanced liver cirrhosis. The Company has completed a Phase 2 clinical trial protocol that is summarized on www.clinicaltrials.gov, trial identifier NCT04112199.
Disclosure
BioVie (BIVI) is a client of RedChip Companies, Inc. BIVI agreed to pay RedChip Companies, Inc., a $7,500 monthly cash fee, beginning in March 2019, for 12 months of RedChip investor awareness services. The CEO of RedChip Companies owns 3,150 shares of BIVI.
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| Esports Entertainment Group (NASDAQ: GMBL) Appoints Two Argyll Executives to Senior Leadership Positions |
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Esports Entertainment Group (NASDAQ: GMBL), a licensed online gambling company with a focus on esports wagering and 18+ gaming, announced the appointment of Argyll Entertainment senior executives Stuart Tilly and Dan Marks as its Corporate Secretary and Chief Financial Officer, respectively.
Key Quote: We’re excited to officially welcome Stuart and Dan to the Esports Entertainment team. As CEO and CFO of Argyll Entertainment, they have proven their ability to execute in our industry, growing the business from start-up to $12 million in revenue annually in just a few short years. As we continue to ramp the Vie.gg platform this experience will be invaluable.” – Grant Johnson, CEO
The Backstory: Esports Entertainment Group is a licensed online gambling company with a specific focus on esports wagering and 18+ gaming. Esports Entertainment offers fantasy, pools, fixed odds and exchange style wagering on esports events in a licensed, regulated and secure platform to the global esports audience at vie.gg. In addition, Esports Entertainment intends to offer users from around the world the ability to participate in multi-player mobile and PC video game tournaments for cash prizes. Esports Entertainment is led by a team of industry professionals and technical experts from the online gambling and the video game industries, and esports. The Company holds a license to conduct online gambling and 18+ gaming on a global basis in Curacao, Kingdom of the Netherlands.
Disclosure
Esports Entertainment Group, Inc. (GMBL) is a client of RedChip Companies, Inc. GMBL agreed to pay RedChip Companies, Inc. a $4,000 monthly cash fee, beginning in June 2018, and 225,000 shares of Rule 144 stock for RedChip investor awareness services.
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| Aptorum Group (NASDAQ: APM) Strengthens Its Presence in US with Appointment of Dr. Kira Sheinerman |
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Aptorum Group (NASDAQ: APM), a biopharmaceutical company focused on the development of novel therapeutics to address global unmet medical needs, today announced the appointment of Dr. Kira Sheinerman as the senior strategic consultant based in New York effective immediately.
Why It Matters: Kira Sheinerman is the co-founder, CEO and Executive Director of DiamiR Biosciences, a molecular diagnostics company focused on developing blood-based tests for early detection and monitoring of brain health conditions. Dr. Sheinerman also serves as a Managing Director, Healthcare Investment Banking at H.C. Wainwright & Co. Previously, she was a Managing Director at Rodman & Renshaw, where she worked on financial and strategic transactions for growth biotech companies with a focus on CNS, oncology, and infectious diseases, as well as molecular diagnostics. Prior to healthcare investment banking, Dr. Sheinerman worked at the Arcus group, a life sciences strategic consulting firm. She is a board member of the Boyce Thompson Institute, an affiliate of Cornell University.
Key Quote: “Dr. Sheinerman has comprehensive professional experience in the life sciences and investment banking sectors, with an outstanding track record working with emerging growth biotech companies. Her expertise would inevitably strengthen our strategic initiatives for the US market and be a valuable addition to our team in enhancing our global expansion plan.” – Ian Huen, CEO
The Backstory: Aptorum is a pharmaceutical company dedicated to developing and commercializing novel therapeutics to tackle unmet medical needs. Aptorum Group’s current drug pipeline includes indications in orphan diseases, infectious diseases, and metabolic diseases, several of which are targeted to enter clinical trial phases in H2 2020. Aptorum Group is also launching a women’s health supplement, Dioscorea Opposita Bioactive Nutraceutical Tablets, which is ready for commercialization.
Disclosure
Aptorum (APM) is a client of RedChip Companies, Inc. APM agreed to pay RedChip Companies, Inc., a $9,000 monthly cash fee, beginning in April 2020, for 12 months of RedChip investor awareness services.
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| Nemaura Medical (NASDAQ: NMRD) Participated as Guest Speaker at DiabetesMine™ D-Data ExChange 2020 |
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Nemaura Medical (NASDAQ: NMRD), a medical technology company focused on developing micro-systems-based wearable diagnostic devices and currently commercializing sugarBEAT®, its non-invasive and flexible continuous glucose monitor ("CGM"), together with BEAT®diabetes, a planned health subscription service designed to help people with Type 2 diabetes and prediabetes through personalized lifestyle coaching, announced Fred Schaebsdau, MD, PhD, Vice President of Strategy and Strategic Alliances, took part as guest speaker at the DiabetesMine™ D-Data Virtual ExChange held on June 12, 2020.
Why It Matters: Dr Schaebsdau showcased Nemaura’s sugarBEAT®, the world’s first non-invasive daily CGM for Type 2 and pre-diabetic patients, as well as the Company’s BEAT®diabetes ecosystem for supporting persons with diabetes to manage their condition better. Dr Schaebsdau discussed the versatility of the platform for continuous non-invasive monitoring, which includes temperature monitoring and monitoring other analytes such as lactate and alcohol. The presentation was well received and underscored the benefits of CGM and "time-in-range" in achieving significantly better outcomes for Type 2 and pre-diabetic patients who currently monitor their blood glucose level with test strips either infrequently or not at all.
The Backstory: Nemaura Medical Inc. (NMRD) is a medical technology company developing micro-systems-based wearable diagnostic devices and currently commercializing sugarBEAT™, and proBEAT™. sugarBEAT®, a CE mark approved Class IIb medical device, is a non-invasive and flexible continuous glucose monitor (CGM) providing actionable insights derived from real time glucose measurements and daily glucose trend data, which may help people with diabetes and pre-diabetes to better manage, reverse and prevent the onset of diabetes. Nemaura is planning to submit a PMA application for sugarBEAT® during the second quarter of 2020 for FDA review of this device under medical device regulations. proBEAT™ comprises a non-invasive glucose monitor and a digital healthcare subscription service and is due to be launched in the US as a general wellness product.
Disclosure
Nemaura Medical (NMRD) is a client of RedChip Companies. NMRD agreed to pay RedChip a monthly cash fee of $6,000 and 15,000 shares of Rule 144 stock for three months of investor awareness services.
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| Learn About Nemaura Medical (NASDAQ: NMRD) in Exclusive Investor Group Call |
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Join Dr. Faz Chowdhury, CEO of Nemaura Medical (NASDAQ: NMRD), for a presentation and live Q&A session to learn about the Company’s recent accomplishments and upcoming milestones this Thursday, June 18, 2020 at 4 pm Eastern.
Call Details:
Thursday, June 18, 2020, 4 pm EST
Conference Line: (866) 821-0302**
**U.S. only. Reach us at (407) 571-0909 for dial-in info for investors outside the U.S.
Disclosure
Nemaura Medical (NMRD) is a client of RedChip Companies. NMRD agreed to pay RedChip a monthly cash fee of $6,000 and 15,000 shares of Rule 144 stock for three months of investor awareness services.
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| Quote of the Week |
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"I'd be a bum on the street with a tin cup if the markets were efficient."
- Warren Buffett |
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| About RedChip |
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| RedChip Companies, an Inc. 5000 company, is an international investor relations, media, and research firm focused on small-cap and mid-cap companies. Since 1992, RedChip has delivered concrete, measurable results for its clients through the most comprehensive service platform in the industry for small-cap and mid-cap companies. These services include a worldwide distribution network for its stock research written by analysts holding the CFA designation; retail and institutional roadshows in major U.S. cities; outbound marketing to stock brokers, RIAs, institutions, and family offices; a digital media investor relations platform that has generated over 2.3 million unique investor views; quarterly global online institutional and retail investor conferences that reach over 10,000 investors annually; "The RedChip Money Report" television show which airs in 100 million homes across the U.S. on The Family Channel; a weekly newsletter delivered to 60,000 investors; TV commercials in local and national markets; corporate and product videos; website design; and traditional investor relation services, which include press release writing, development of investor presentations, quarterly conference call script writing, strategic consulting, capital raising, and more. |
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| RedChip Disclosure |
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RedChip Companies, Inc. research reports, company profiles and other investor relations materials, publications or presentations, including web content, are based on data obtained from sources we believe to be reliable but are not guaranteed as to accuracy and are not purported to be complete. As such, the information should not be construed as advice designed to meet the particular investment needs of any investor. Any opinions expressed in RedChip reports, company profiles, or other investor relations materials and presentations are subject to change. RedChip Companies and its affiliates may buy and sell shares of securities or options of the issuers mentioned on this website at any time.
RedChip Visibility is a division of RedChip Companies, Inc. and offers research services to paying clients. In the purview of Section 17(b) of the Securities Act of 1933 and in the interest of full disclosure, we call the reader's attention to the fact that the RedChip Companies Inc. is an investor relations firm hired by certain Companies to increase investor awareness to the small-cap equity community.
Stock market investing is inherently risky. RedChip Companies is not responsible for any gains or losses that result from the opinions expressed on this website, in its research reports, company profiles or in other investor relations materials or presentations that it publishes electronically or in print.
We strongly encourage all investors to conduct their own research before making any investment decision. For more information on stock market investing, visit the Securities and Exchange Commission ("SEC") at www.sec.gov and view RedChip’s Disclosures. |
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